Endocrine Abstracts

GLP-1 stimulates β-cell proliferation, it also enhances the differentiation of new beta cells from progenitor cells in the pancreatic duct epithelium and it is capable of inhibiting apoptosis of β cells. GLP-1 also exhibits other effects of importance for glucose homeostasis, such as, inhibiting glucagon secretion, delaying gastric emptying, and stimulating insulin biosynthesis. These effects come along with a potential increase in peripheral insulin action. Type 2 d...

GLP-1 stimulates β-cell proliferation, it also enhances the differentiation of new beta cells from progenitor cells in the pancreatic duct epithelium and it is capable of inhibiting apoptosis of beta cells. GLP-1 also exhibits other effects of importance for glucose homeostasis, such as, inhibiting glucagon secretion, delaying gastric emptying, and stimulating insulin biosynthesis. These effects come along with a potential increase in peripheral insulin action. Type 2 dia...

Introduction: Egypt has an epidemic of HCV. Interferon (IFN) is the drug of choice for treatment induces autoimmune thyroiditis. The biochemical characteristic of the autoimmune thyroid disorder is the presence of autoantibodies against thyroid peroxidase and thyroglobulin. Chemokine ligand 10 (CXCL10) is an IFN inducible chemokine involved in the autoimmune thyroid disease.Aim: To assess the incidence of autoimmune thyroid disorder following treatment w...

Background: TSH secretion shows a diurnal rhythm with a surge in the evening. The nocturnal surge is essential for thyroid function regulation. TSH surge is suggested to be blunted in central hypothyroidism. In idiopathic short stature (ISS), thyroid dysfunction has been suggested ranging from mild hypothyroidism to central hypothyroidism.Aim of the work: To study the pituitary thyroid axis and the TSH surge in ISS.Materials and me...

Background: TSH surge is the most sensitive test currently available for confirming the diagnosis of central hypothyroidism, a hidden cause of idiopathic short stature.Objective: Studying the nocturnal TSH surge in children with the idiopathic shot stature.Patients and method: The study included 30 healthy children (10–18 years) as a control group and 30 children of matching age and sex with ISS as a patients group. TSH was me...